Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma.

Reversal of Electrocardiographic Sodium Channel Blockade Changes with Bicarbonate Therapy in a Pediatric Patient Post-Cardiopulmonary Arrest Secondary to Methadone Toxicity

What is the role of lidocaine or phenytoin in tricyclic antidepressant-induced cardiotoxicity? Lidocaine and phenytoin in TCA cardiotoxicity

Introduction. Tricyclic antidepressant (TCA) poisoning is a relatively common occurrence and remains a significant cause of mortality and morbidity. Deaths from TCA toxicity are typically due to cardiovascular events such as arrhythmias and hypotension. Cardiovascular toxicity may be multifactorial. However, the primary mechanism is a TCA-induced membrane-depressant or “quinidine-like” effect o...

Novel derivatives of phthalimide with potent anticonvulsant activity in PTZ and MES seizure models

Objective(s): Phthalimide-based derivatives have anticonvulsant activity like as phenytoin by inhibition of sodium channel. In our previously research we mentioned about some phthalimide derivatives as potent anticonvulsant agents. Materials and Methods: Fourteen analogs of 2-substituted phthalimide pharmacophore were synthesized and then were evaluated for the anticonvulsant activities in pent...

What is the role of lidocaine or phenytoin in tricyclic antidepressant-induced cardiotoxicity?

INTRODUCTION Tricyclic antidepressant (TCA) poisoning is a relatively common occurrence and remains a significant cause of mortality and morbidity. Deaths from TCA toxicity are typically due to cardiovascular events such as arrhythmias and hypotension. Cardiovascular toxicity may be multifactorial. However, the primary mechanism is a TCA-induced membrane-depressant or "quinidine-like" effect on...

Centrally Mediated Anti-Hyperalgesic and Anti-Allodynic Effect of Tolperisone in Spared Nerve Injury Model of Neuropathic Pain

Neuropathic pain is caused by a lesion or disease of somatosensory nervous system and its treatment remains a challenge. The purpose of the present study was to evaluate efficacy of Tolperisone, a centrally acting muscle relaxant in reducing neuropathic pain and also attempt to establish its mechanism of action by comparing its effectiveness with standard drug Phenytoin. Neuropathic pain was in...